Li P, Fan C, Lu Y, Qi K*. Effects of Calcium Supplementation on the Body Weight: A Meta-Analysis. Am J Clin Nutr.2016; 104(5):1263-1273（SCI, IF 6.703）
Abstract Background: Whether calcium supplementation reduces body weight and prevents obesity remains unclear because of inconsistent reports. Objective: This meta-analysis was performed to investigate the correlations between calcium intake and changes in body weight based on subjects’ age, gender and BMI and length of calcium intervention. Design: The PubMed, EMBASE, Web of Knowledge and China National Knowledge Infrastructure (CNKI) databases were systematically searched to select relevant studies published from 1994 to 2016. Both randomized controlled trials and longitudinal studies of calcium supplementation were included, and a random effects model in RevMan 5.3 software was used for data analysis. Results: Thirty-three studies involving a total of 4,733 participants were included in this meta-analysis. No significant differences in weight loss were found between the calcium intervention and the control groups (-0.01, 95%CI -0.02, 0.00 kg) (P=0.12). However, negative correlations between calcium supplementation and weight changes were shown in children and adolescents (-0.26, 95%CI -0.41, -0.11 kg) (P<0.001) and adult men and premenopausal women (-0.91, 95%CI -1.38, -0.44 kg) (P<0.001), but not in postmenopausal women (-0.14, 95%CI -0.54, 0.26 kg) (P=0.50). Considering BMI, a negative correlation between calcium supplementation and weight changes were observed in subjects with a normal BMI (-0.53, 95%CI -0.89, -0.16 kg) (P=0.005) but not in overweight or obese subjects (-0.35, 95%CI -0.81, 0.11 kg) (P=0.14). Compared to the control groups, no differences in weight change were shown in the calcium intervention groups when the calcium intervention was shorted (-0.09, 95%CI -0.45, 0.26 kg) (P=0.60) or longer than 6 months (-0.01, 95%CI -0.02, 0.01 kg) (P=0.46). Conclusions: Increasing calcium intake through calcium supplements could reduce body weight in subjects who have a normal BMI or in children, adolescents, adult men and premenopausal women.